Twitter api v1.1 require authentification everywhere. You must create account at http://dev.twitter.com and create app for consumer and access keys.
In Python, you may use oauth2 library.
import oauth2
CONSUMER_KEY = "your app's consumer key"
CONSUMER_SECRET = "your app's consumer secret"
ACCESS_KEY = "your access token"
ACCESS_SECRET = "your access token secret"
consumer = oauth2.Consumer(key=CONSUMER_KEY, secret=CONSUMER_SECRET)
access_token = oauth2.Token(key=ACCESS_KEY, secret=ACCESS_SECRET)
client = oauth2.Client(consumer, access_token)
endpoint = "http://api.twitter.com/1.1/statuses/home_timeline.json"
response, data = client.request(endpoint)
print data